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The ALS Therapy Development Institute (ALS TDI) is a non-profit biotechnology company seeking effective treatments for amyotrophic lateral sclerosis (ALS). It is a registered 501(c)(3) non-profit organization in the United States. It operates the world's largest research and development program focused on ALS. ALS TDI has conducted pre-clinical investigations (using the G93A ALS mouse model) and efficacy studies on more potential treatments than any other research facility. Many of the findings from these tests are posted online with data freely available. The institute has worked with dozens of collaborators from both academia and industry, most recently entering into agreements with Gene Logic, Microbix, Aptagen and the Allen Institute for Brain Science. Through its partnerships and the organization of significant research talent at its facility, the Institute is focusing resources on using powerful genomic and proteomic information to stop the disease. ==History== In 2007, ALS TDI changed its name to ALS TDI from ALS Therapy Development Foundation (ALS TDF) corresponding with a major grant and research partnership with the MDA's Augie's Quest. ALS TDI was founded in 1999 by James Heywood, Robert Bonazoli, and Melinda Marsh Heywood after James' brother, Stephen Heywood, was diagnosed with the disease. Dr. Tennore Ramesh joined ALS-TDF when his sister in law was diagnosed with ALS and set up the research facility and served as chief scientific officer from inception until 2003.〔http://www.als.net/aboutus/ourstory.asp〕 James Heywood served as the d'Arbeloff Founding Director and CEO of the Institute from 1999–2007, when he joined the board. Following Heywood's move to the Board, Sean F. Scott was named the Institute's President. Sean's family has a history of ALS caused by an inherited form of the neurodegenerative disease. Mr. Nieto, a fitness pioneer and ALS patient himself, worked with Sean and MDA VP of Translational Research, Sharon Hesterlee, to bring together the MDA and ALS TDI in 2007. Today, the Institute is run by Steven Perrin, Ph.D., a genomic expert with more than 15 years of experience in the biotech and pharma industries. Perrin leads a team of more than 30 industry trained scientists and technicians that conduct research in the Institute's facility in biotech rich Cambridge, Mass. Several additional organizations are in the process of mimicking the ALS TDI model, including the Scleroderma Foundation, the Myelin Repair Foundation, Autism Speaks, Michael J. Fox Foundation, and CHDI, an organization searching for medicines to treat Huntington's disease.〔http://journals.lww.com/neurologynow/Fulltext/2010/06050/The_CEO_of_ALS_Research.11.aspx〕 The Institute has raised and spent nearly $60 million on research into effective treatments for ALS and published several works that have helped to further the field of neurodegenerative research, including: ''Design, Power and Interpretation of Studies in the Standard Murine Model of ALS'' (Scott, ''et al.'', ALS Volume 9(1):4-15, 2008) ''From Transcriptome Analysis to Therapeutic Anti-CD40L Treatment in the SOD1 Model of Amytrophic Lateral Sclerosis'' (Lincecum, ''et al.'', Nature Genetics, Volume 42, May 2010)〔http://www.nature.com/ng/journal/v42/n5/abs/ng.557.html〕 ALS, also known as Lou Gehrig’s disease, is a neurodegenerative disorder that paralyzes the body but leaves the mind intact. ALS is not rare; 350,000 patients have it worldwide. Patients live on average two-to-five years following diagnosis. There is no cure and no effective treatment. ALS TDI practices open-source science and maintains a patient and research-focused discussion forum. Some of the Institute's funding comes from grassroots fundraising events organized by ALS patients, their families and supporters. The Institute, and the story of its origins were captured by the award-winning documentary "So Much So Fast". 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「ALS Therapy Development Institute」の詳細全文を読む スポンサード リンク
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